Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata, Found in a Screening Study Monitored by Immunomodulatory Activity

書誌事項

タイトル別名
  • Six Immunosuppressive Features from an Ascomycete, Zopfiella ion gicaudata, Found in a Screening Study Monitored by Immunomodulatory Activity
公開日
2004
資源種別
journal article
DOI
  • 10.1248/cpb.52.1005
  • 10.1002/chin.200502195
公開者
公益社団法人 日本薬学会

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説明

In a screening study on immunomodulatory fungal metabolites, three known anthraquinones, carviolin (roseo-purpurin) (1), 1-O-methylemodin (2), ω-hydroxyemodin (citreorosein) (4), and a new anthraquinone, ω-acetylcarviolin (3), together with a known steroid, ergosta-4,6,8(14),22-tetraen-3-one (5) and a new steroid, 25-hydroxyergosta-4,6,8(14),22-tetraen-3-one (6) were isolated from an Ascomycete, Zopfiella longicaudata, and found to have moderate immunosuppressive activities. The structure–activity relationships of these metabolites are discussed.

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