Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity

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  • Panteleon Vassiliki
    Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
  • Kostakis Ioannis K.
    Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
  • Marakos Panagiotis
    Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
  • Pouli Nicole
    Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
  • Andreadou Ioanna
    Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens

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The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine–xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.

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