Synthesis and DNA Polymerase .ALPHA. and .BETA. Inhibitory Activity of Alkyl p-Coumarates and Related Compounds

DOI Web Site Web Site PubMed 1 Citations 7 References Open Access
  • Nishimura Katsumi
    Kobe Pharmaceutical University
  • Takenaka Yukiko
    Kobe Pharmaceutical University
  • Kishi Manami
    Kobe Pharmaceutical University
  • Tanahashi Takao
    Kobe Pharmaceutical University
  • Yoshida Hiromi
    Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University Cooperative Research Center of Life Sciences, Kobe-Gakuin University
  • Okuda Chiaki
    Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University
  • Mizushina Yoshiyuki
    Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University Cooperative Research Center of Life Sciences, Kobe-Gakuin University

Bibliographic Information

Other Title
  • Synthesis and DNA polymerase α and β inhibitory activity of alkyl p-coumarates and related compounds
  • Synthesis and DNA polymerase a and v inhibitory activity of alkyl p coumarates and related compounds

Search this article

Description

trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases α and β. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases α and β.

Journal

Citations (1)*help

See more

References(7)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top