Two New Lactones and One New Aryl-8-oxa-bicyclo[3,2,1]oct-3-en-2-one from Descurainia sophia

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  • Sun Kai
    Research Department of Natural Medicine, Shenyang Pharmaceutical University
  • Li Xian
    Research Department of Natural Medicine, Shenyang Pharmaceutical University
  • Li Wen
    The Center of Instrumental Analysis, Shenyang Pharmaceutical University
  • Wang Jinhui
    Research Department of Natural Medicine, Shenyang Pharmaceutical University
  • Liu Jianming
    Research Department, Yisheng Pharmaceutical Co. Ltd.
  • Sha Yi
    The Center of Instrumental Analysis, Shenyang Pharmaceutical University

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説明

Two new lactones (1, 2), descurainolide A and B, and one new aryl-8-oxa-bicyclo[3,2,1]-oct-3-en-2-one (3), descurainin, together with five known compounds (4—8), were isolated from the seeds of Descurainia sophia (L.) WEBB ex PRANTL. The structures of the new compounds were elucidated by extensive studies of their 1D, 2D NMR and HR-MS. Compounds 4 and 5 showed cytotoxicity.

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