New Norditerpenoids with Trypanocidal Activity from Vitex trifolia
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- Kiuchi Fumiyuki
- Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Japan
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- Matsuo Kenji
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- Ito Michiho
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- Qui Tran Kim
- Research Center for Applied Chemistry, Vietnam National University
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- Honda Gisho
- Graduate School of Pharmaceutical Sciences, Kyoto University
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抄録
Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 52 (12), 1492-1494, 2004
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679147460480
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- NII論文ID
- 110003665484
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 7173514
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- PubMed
- 15577254
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可