Nucleosides: XI. Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs

DOI Web Site Web Site PubMed 1 Citations 60 References
  • Chien Tun-Cheng
    School of Pharmacy, College of Medicine, National Taiwan University No. 1, Section 1
  • Chen Chien-Shu
    School of Pharmacy, College of Medicine, National Taiwan University No. 1, Section 1
  • Yu Fang-Hwa
    School of Pharmacy, College of Medicine, National Taiwan University No. 1, Section 1
  • Chern Ji-Wang
    School of Pharmacy, College of Medicine, National Taiwan University No. 1, Section 1

Bibliographic Information

Other Title
  • Nucleosides (6) Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs

Search this article

Description

4-Amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) was prepared by a direct glycosylation of 4-aminoquinazolin-2-one (7) using the Vorbruggen's silylation method and provided exclusively the β-anomer. This quinazoline nucleoside and its 2′,3′-O-isopropylidene derivative (9) did not undergo the coupling reaction with dialkyl disulfides in the presence of tri-n-butylphosphine unless their 4-amino groups were protected by N,N-dimethylaminomethylidene. This approach provides a viable alternative synthetic route to 5′-alkylthio-5′-deoxy nucleosides.

Journal

Citations (1)*help

See more

References(60)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top