Cytotoxic and Anti-oxidant Activities of Lanostane-Type Triterpenes Isolated from Poria cocos

DOI Web Site Web Site 被引用文献1件 参考文献35件
  • Zhou Liang
    Department of Pharmacy, National University of Singapore
  • Zhang Yaochun
    Department of Pharmacy, National University of Singapore
  • Gapter Leslie Adell
    Department of Pharmacy, National University of Singapore
  • Ling Hui
    Department of Pharmacy, National University of Singapore
  • Agarwal Rajesh
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver and Health Sciences Center
  • Ng Ka-yun
    Department of Pharmacy, National University of Singapore

書誌事項

公開日
2008
DOI
  • 10.1248/cpb.56.1459
公開者
公益社団法人 日本薬学会

この論文をさがす

説明

A new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16α-hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5), 3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and dehydrotumulosic acid (9). The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. Although none of the nine (1 to 9) compounds showed promising antioxidant activity, 1 through 6 and 8 showed good cytotoxicity against human lung cancer cell line A549 and human prostate cancer cell line DU145. Interestingly, all these compounds exhibited better cytotoxicity towards A549 than DU145 cells.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (35)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ