Scale-Up of Wet Kneading in a Novel Vertical High Shear Kneader
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- Watano Satoru
- Osaka Prefecture University
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- Okamoto Takumi
- Osaka Prefecture University
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- Sato Yoshinobu
- Osaka Prefecture University
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- Ohnishi Yoshito
- Taiho Pharmaceutical Co., Ltd.
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- Yasutomo Teruhito
- Taiho Pharmaceutical Co., Ltd.
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- Osako Yoshifumi
- Fuji Paudal Co., Ltd.
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Abstract
A novel multi-functional vertical high shear kneader has been developed and its performance in wet kneading has previously been reported [Watano et al., Chem. Pharm. Bull., 50(3), 341—345 (2002)]. In this study, scale-up of wet kneading in the novel vertical high shear kneader was conducted. Pharmaceutical excipients composed of lactose, cornstarch and micro-crystalline cellulose were used as powder samples. Kneading operations were conducted under various operating conditions and three different vessel scales. The dried pellets were then prepared by extruding the wet kneaded masses through a dome-type extruder and their drying by a fluidized bed. The physical properties such as strength and disintegration time of the dried pellets were evaluated. It was found that the properties of the dried pellets and their scale-up characteristics were well expressed by an agitation power per unit vessel volume and dimensionless Froude number.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 53 (1), 18-21, 2005
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679147591936
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- NII Article ID
- 10016651285
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 7200632
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- PubMed
- 15635222
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed