Catalytic aerobic oxidation of nor-binaltorphimine (nor-BNI) analogs without 4,5-epoxy bridge affords a more selective ligand for k opioid receptor than the representative k antagonist nor-BNI
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- Osa Yumiko
- School of Pharmacy, Kitasato University
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- Ida Yoshihiro
- School of Pharmacy, Kitasato University
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- Fujii Hideaki
- School of Pharmacy, Kitasato University
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- Nemoto Toru
- School of Pharmacy, Kitasato University
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- Hasebe Ko
- Pharmaceutical Research Laboratories, Toray Industries, Inc.
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- Momen Shinobu
- Pharmaceutical Research Laboratories, Toray Industries, Inc.
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- Mochizuki Hidenori
- Pharmaceutical Research Laboratories, Toray Industries, Inc.
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- Nagase Hiroshi
- School of Pharmacy, Kitasato University
書誌事項
- タイトル別名
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- Catalytic Aerobic Oxidation of nor-Binaltorphimine (nor-BNI) Analogs without 4,5-Epoxy Bridge Affords a More Selective Ligand for .KAPPA. Opioid Receptor than the Representative .KAPPA. Antagonist nor-BNI
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抄録
An analog of nor-binaltorphimine (nor-BNI) without the 4,5-epoxy bridge, 17,17′-bis(cyclopropylmethyl)-6,6′,7,7′-tetrahydro-6,6′-imino-14β,14′α-dihydroxy-3,3′-dimethoxy-7,7′-bimorphinan (4), which was the precursor of the designed compound 1 as a selective κ3 opioid receptor antagonist, was catalytically oxidized with oxygen in the presence of platinum to give the 5′-oxo derivative 3 with some other oxidized products. Morphinan derivatives without the 4,5-epoxy moiety were labile to oxygen, although the corresponding 4,5-epoxymorphinan derivatives resisted aerobic oxidation. One of the oxidized nor-BNI analogs without 4,5-epoxy bridge, compound 18, showed high affinity and selectivity for κ opioid receptor.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 55 (10), 1489-1493, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679147621760
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- NII論文ID
- 110006404698
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 8918962
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可