Electroreduction of the Muscle Relaxant Drug Dantrolene Sodium at the Mercury Electrode and Its Determination in Bulk Form and Pharmaceutical Formulation

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The electroreduction of the muscle relaxant drug dantrolene sodium at the mercury electrode has been studied in the Britton–Robinson universal buffer of pH 2.5—11.5 containing 20% (v/v) methanol by means of dc-polarography, cyclic voltammetry and controlled-potential coulometry. Its reduction took place via three irreversible cathodic steps in solutions of pH ≤6, two steps in solutions of 6<pH<10 and a single step at pH values ≥10 through the consumption of 10, 8 or 4 electrons, respectively. This behavior was attributed to the reduction of NO2 group (1st and 2nd steps at pH ≤6 or the single step at pH ≥10) and the –CH=N– double bond (3rd step at pH <10). Two polarographic procedures (direct current and differential-pulse modes) and three adsorptive cathodic stripping voltammetric procedures (linear-sweep, differential-pulse and square-wave modes) were described and successfully applied for quantification of dantrolene sodium in its bulk form and in pharmaceutical formulation (Dantrolex tablets).

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