Concise Synthesis of Dimemorfan (DF) Starting from 3-Hydroxymorphinan (3-HM)
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- Kim Jong Yup
- Small Molecule Group, Central Research Institute, Green Cross Corporation
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- Kim Hyoung-Chun
- College of Pharmacy, Kangwon National University
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- Kim Jeongmin
- Small Molecule Group, Central Research Institute, Green Cross Corporation
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- Lee Jinhwa
- Small Molecule Group, Central Research Institute, Green Cross Corporation
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Description
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 56 (7), 985-987, 2008
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679147634176
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- NII Article ID
- 110006791981
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 9544839
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed