Determination of Diclofenac Sodium in Commercial Pharmaceutical Formulations and Human Control Serum Using a Kinetic-Spectrophotometric Method
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- Mitić Snežana
- Faculty of Sciences and Mathematics, Department of Chemistry, University of Niš
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- Miletić Gordana
- Faculty of Sciences and Mathematics, Department of Chemistry, University of Niš
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- Pavlović Aleksandra
- Faculty of Sciences and Mathematics, Department of Chemistry, University of Niš
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- Tošić Snežana
- Faculty of Sciences and Mathematics, Department of Chemistry, University of Niš
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- Pecev Emilija
- Faculty of Sciences and Mathematics, Department of Chemistry, University of Niš
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A kinetic method for the determination of micro quantities of diclofenac sodium (DS) is described in this paper. The method is based on a ligand-exchange reaction. The reaction was followed spectrophotometrically by monitoring the rate of appearance of the cobalt diclofenac complex at 376 nm. The optimum operating conditions regarding reagent concentrations and temperature were established. The optimized conditions yielded a theoretical detection limit of 1.29 μg ml−1 based on the 3Sb criterion. The interference effects of certain drugs, foreign ions and amino acids upon the reaction rate were studied in order to assess the selectivity of the method. The developed procedure was successfully applied to the rapid determination of diclofenac sodium in commercial pharmaceutical preparations and human control serum. The unique features of this procedure are that determination can be carried out at room temperature and the analysis time is short. The newly developed method is simple, inexpensive, and efficient for use in the analysis of a large number of samples.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 55 (10), 1423-1426, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679147648128
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- NII論文ID
- 110006404686
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 8918455
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可