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Alkinonase A and AF, New Alkaline Proteinases produced by <I>Streptomyces violaceorectu8</I>
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- NAKAMURA SHOSHIRO
- Pharmaceutical Institute, Hiroshima University School of Medicine
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- FUKUDA HIDEO
- Pharmaceutical Institute, Hiroshima University School of Medicine
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- YAMAMOTO TAKUZO
- Institute of Microbial Chemistry
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- OGURA MICHIKO
- Institute of Microbial Chemistry
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- HAMADA MASA
- Institute of Microbial Chemistry
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- MATSUZAKI MEIKI
- Institute of Microbial Chemistry
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- UMEZAWA HAMAO
- Institute of Microbial Chemistry
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Description
Alkaline proteinases, named alkinonase A and AF, are isolated from the cultured broth of Streptomyces violaceorectus. Both alkinonases show remarkably strong antiinflammatory activity for the carrageenin-induced edema. Alkinonase A and AF are belonging to a new type of alkaline proteinases of microbial origin. The effect of inhibitors on the proteolytic activity and the substrate specifities of alkinonases are resembled to that of the neutral proteinases of microbial origin and different from that of the alkaline proteinases of microbial origin. Production, isolation, purification, effect of pH on the proteolytic activity, pH stability, effect of temperature on the proteolytic activity, effect of inhibitors on the proteolytic activity, substrate specifities and anti-inflammatory activity for the carrageenin induced edema of alkinonases are described in this paper.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 20 (2), 385-390, 1972
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679147671552
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- NII Article ID
- 130003766944
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- COI
- 1:CAS:528:DyaE38Xht1egsLs%3D
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- ISSN
- 13475223
- 00092363
- http://id.crossref.org/issn/00092363
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- PubMed
- 5032473
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed