Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-.ALPHA. Inhibitory Activity from the Flowers of Punica granatum

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  • Xie Yuanyuan
    Pharmaceutical Research and Technology Institute, Kinki University School of Traditional Chinese Medicine, Shenyang Pharmaceutical University
  • Morikawa Toshio
    Pharmaceutical Research and Technology Institute, Kinki University
  • Ninomiya Kiyofumi
    Pharmaceutical Research and Technology Institute, Kinki University
  • Imura Katsuya
    Pharmaceutical Research and Technology Institute, Kinki University
  • Muraoka Osamu
    Pharmaceutical Research and Technology Institute, Kinki University
  • Yuan Dan
    School of Traditional Chinese Medicine, Shenyang Pharmaceutical University
  • Yoshikawa Masayuki
    Pharmaceutical Research and Technology Institute, Kinki University Kyoto Pharmaceutical University

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  • Medicinal flowers (23) New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-α inhibitory activity from the flowers of Punica granatum
  • Medicinal flowers 23 New taraxastane type triterpene punicanolic acid with tumor necrosis factor a inhibitory activity from the flowers of Punica granatum
  • Medicinal flowers. XXIII. New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-α inhibitory activity from the flowers of Punica granatum

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The methanolic extract from the flowers of Punica granatum L. (Punicaceae) was found to show inhibitory effect on tumor necrosis factor-α (TNF-α, 1 ng/ml)-induced cytotoxicity in L929 cells. By bioassay-guided separation, a new taraxastane-type triterpene, punicanolic acid (1), was isolated from the active fraction (ethyl acetate-soluble fraction) together with four triterpenes (2—5), two galloyl glucoses (6, 7), two flavones (8, 9), and β-sitosterol. Among the constituents, 1, oleanolic acid (2), maslinic acid (4), 1,2,6-tri-O-galloyl β-D-glucopyranoside (6), 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl β-D-glucopyranoside (7), and luteolin (8) significantly inhibited TNF-α-induced cytotoxicity in L929 cells at 30 μM.

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