Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with .GAMMA.-Cyclodextrin Formed by Solubility Method
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- Nishimura Katsunori
- Graduate School of Pharmaceutical Sciences, Kumamoto University
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- Higashi Taishi
- Graduate School of Pharmaceutical Sciences, Kumamoto University
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- Yoshimatsu Ayumi
- Graduate School of Pharmaceutical Sciences, Kumamoto University
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- Hirayama Fumitoshi
- Faculty of Pharmaceutical Sciences, Sojo University
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- Uekama Kaneto
- Faculty of Pharmaceutical Sciences, Sojo University
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- Arima Hidetoshi
- Graduate School of Pharmaceutical Sciences, Kumamoto University
Bibliographic Information
- Other Title
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- Pseudorotaxane-like supramolecular complex of coenzyme Q10 with γ-cyclodextrin formed by solubility method
- Pseudorotaxane like supramolecular complex of coenzyme Q10 with g cyclodextrin formed by solubility method
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Description
The purpose of this study is to reveal whether Coenzyme Q10 (CoQ10) forms pseudorotaxane-like supramolecular complex with γ-cyclodextrin (γ-CyD). The poorly soluble complex of CoQ10 with γ-CyD in water was prepared by the solubility method. The X-ray diffraction pattern of the CoQ10/γ-CyD complex was different from that of the physical mixture, but almost the same as that of polypropylene glycol (PPG)/γ-CyD polypseudorotaxane. Also, the differential scanning calorimetrical study and FT-IR study demonstrated the interaction between CoQ10 and γ-CyD in the solid state. The 1H-NMR study and the yield study of the supramolecular complex of CoQ10 with γ-CyD demonstrated that the stoichiometry was 5 : 1 (γ-CyD : CoQ10). The dispersion rate of CoQ10 was markedly increased by the formation of the supramolecular complex with γ-CyD, possibly due to submicron-ordered particle formulation. In fact, CoQ10 was found to form submicron-sized supramolecular particles with γ-CyD, when prepared by the solubility method. Consequently, the present study showed that CoQ10 forms the pseudorotaxane-like supramolecular complex with γ-CyD in water.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 56 (5), 701-706, 2008
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679147808000
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- NII Article ID
- 110006663996
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 9473850
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed