Preparation, Characterization and in Vitro Anticancer Activity of Platinum(II) Complexes with N-Cyclohexyl-1,3-propanediamine as the Carrier
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- Liu Weiping
- Platinum-Based Drug Lab, Kunming Institute of Precious Metals
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- Qing Chen
- Kunming Medical College
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- Chen Xizhu
- Platinum-Based Drug Lab, Kunming Institute of Precious Metals
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- Ye Qingsong
- Platinum-Based Drug Lab, Kunming Institute of Precious Metals
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- Yu Yao
- Platinum-Based Drug Lab, Kunming Institute of Precious Metals
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- Hou Shuqian
- Platinum-Based Drug Lab, Kunming Institute of Precious Metals
Bibliographic Information
- Other Title
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- Preparation, characterization and in vitro anticancer activity of platinum(2) complexes with N-cyclohexyl-1,3-propanediamine as the carrier
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Abstract
New JM118 (active form of satraplatin) analogues with N-cyclohexyl-1,3-propanediamine (N-chpda) as the carrier, cis-[Pt(N-chpda)X2] (X2=2Cl− (1), oxalate (2), malonate (3), 1,1-cyclobutanedicarboxylate (CBDCA) (3), and 3-hydroxy-1,1-cyclobutanedicarboxylate(HO-CBDCA) (4)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative compound cis-[Pt(N-chpda)Cl2].The complexes have also been evaluated for their in vitro anticancer activity. All these analytical data are in good agreement with the structures of the desired compounds. The Pt(II) is in a square planar environment and is coordinated by a chelating N-chpda ligand and 2Cl− in cis position, and there are two crystallographically independent cis-[Pt(N-chpda)Cl2] molecules linked together by intermolecular N–H···Cl hydrogen bonds. Compounds 1 and 2 are very active against human lung cancer cell line (AGZY) and human lymphocytic leukemia cell line (Raji), and are much more active than carboplatin. Platinum(II) complexes with N-cyclohexyl-1,3-propanediamine is an alternative choice for mixed ammine/aminoplatinum anticancer drugs.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 56 (5), 659-662, 2008
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679147820544
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- NII Article ID
- 110006663987
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 9473621
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed