Recent Developments in the Maytansinoid Antitumor Agents

DOI Web Site Web Site PubMed 11 Citations 255 References

Search this article

Abstract

Maytansine and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. Many of these compounds are antitumor agents of extraordinary potency, yet phase II clinical trials with maytansine proved disappointing. The chemistry and biology of maytansinoids has been reviewed repeatedly in the late 1970s and early 1980s; the present review covers new developments in this field during the last two decades. These include the use of maytansinoids as “warheads” in tumor-specific antibodies, preliminary metabolism studies, investigations of their biosynthesis at the biochemical and genetic level, and ecological issues related to the occurrence of such typical microbial metabolites in higher plants.

Journal

Citations (11)*help

See more

References(255)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top