Indirect Potentiometric Titration of Ascorbic Acid in Pharmaceutical Preparations Using Copper Based Mercury Film Electrode
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- Abdul Kamal Nazer Meeran Mohideen
- Department of Chemistry, The New College, Chennai
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- Hameed Abdul Rahman Shahul
- Department of Chemistry, The New College, Chennai
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- Riyazuddin Patel
- Department of Analytical Chemistry, University of Madras
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Abstract
A simple and rapid potentiometric method for the estimation of ascorbic acid in pharmaceutical dosage forms has been developed. The method is based on treating ascorbic acid with iodine and titration of the iodide produced equivalent to ascorbic acid with silver nitrate using Copper Based Mercury Film Electrode (CBMFE) as an indicator electrode. Interference study was carried to check possible interference of usual excipients and other vitamins. The precision and accuracy of the method was assessed by the application of lack-of-fit test and other statistical methods. The results of the proposed method and British Pharmacopoeia method were compared using F and t-statistical tests of significance.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 52 (1), 38-40, 2004
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679147994240
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- NII Article ID
- 110003615474
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 6794669
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- PubMed
- 14709865
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed