The Structure of 9, 14-Epoxy-8, 14-seco Steroids

  • ASAKO TSUNEHIKO
    Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
  • HIRAGA KENTARO
    Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
  • MIKI TAKUICHI
    Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

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説明

The more stable compound, 9, 14α-epoxy-3-methoxy-8, 14-secoestra-1, 3, 5 (10)-trien-17-one (IVa), given by cyclization of 14α-hydroxy-3-methoxy-8, 14-secoestra-1, 3, 5 (10), 9-tetraen-17-one (II), has been assigned to a 9α, 14α-epoxy compound (9S configuration).

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