Synthesis, Characterization and Biological Evaluation of Platinum(II) Complexes with a Chiral N-Monosubstituted 1,2-Cyclohexyldiamine Derivative

DOI Web Site Web Site 23 References
  • Gao Chuanzhu
    Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University
  • Gou Shaohua
    Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, Southeast University Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University
  • Xu Gang
    Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, Southeast University Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University

Bibliographic Information

Other Title
  • Synthesis, characterization and biological evaluation of platinum(2) complexes with a chiral N-monosubstituted 1,2-cyclohexyldiamine derivative

Search this article

Description

Eight platinum(II) compounds with a new chiral ligand, 2-(((1R,2R)-2-aminocyclohexylamino)methyl)phenol (HL), were designed, prepared and spectrally characterized. All compounds showed better aqueous solubility than cisplatin and oxaliplatin. In vitro cytotoxicity of these compounds against human HepG-2, MCF-7, A549 and HCT-116 cell lines was evaluated. Results indicated that all compounds showed cytotoxicity against A549 and HepG-2 cell lines. Particularly, compounds B1 and B8, which have CF3SO3− and (CH3)3COCH2COO− as leaving groups, respectively, exhibited better cytotoxicitiy than that of carboplatin in these two cell lines.

Journal

References(23)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top