Synthesis of D- and L-Selenomethionine Double-Labeled with Deuterium and Selenium-82
-
- Matsukawa Takehisa
- Juntendo University School of Medicine
-
- Hasegawa Hiroshi
- School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
-
- Shinohara Yoshihiko
- School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
-
- Kobayashi Jun
- Juntendo University School of Medicine
-
- Shinohara Atsuko
- Juntendo University School of Medicine Research Institute for Cultural Science, Seisen University
-
- Chiba Momoko
- Juntendo University School of Medicine
-
- Ichida Kimiyoshi
- School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
-
- Yokoyama Kazuhito
- Juntendo University School of Medicine
Search this article
Abstract
The synthesis of D- and L-selenomethionine labeled with 82Se and three deuteriums at Se-methyl group (D- and L-[2H3, 82Se]selenomethionine) was described. D- And L-[2H3, 82Se]selenomethionine were prepared by condensation of (R)- and (S)-2-amino-4-bromobutylic acid with lithium [2H3, 82Se]methaneselenolate, which was prepared from metal 82Se and [2H3]methyl iodide. The optical purities of D- and L-[2H3, 82Se]selenomethionine were determined by HPLC with a chiral stationary phase column and were found more than 99% ee. The chemical ionization mass spectra showed that the molecular related ion for N-isobutyloxycarbonyl ethyl ester derivatives of [2H3, 82Se]selenomethionine did not overlap with the m/z values known from that of non-labeled selenomethionine.
Journal
-
- Chemical and Pharmaceutical Bulletin
-
Chemical and Pharmaceutical Bulletin 58 (12), 1658-1660, 2010
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679149079040
-
- NII Article ID
- 130000405700
-
- NII Book ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL BIB ID
- 10894977
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed