Influence of Compression Pressure and Velocity on Tablet Sticking
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- Kakimi Kazuyuki
- Faculty of Pharmacy, Meijo University
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- Niwa Toshiyuki
- Faculty of Pharmacy, Meijo University
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- Danjo Kazumi
- Faculty of Pharmacy, Meijo University
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抄録
A rotary tablet machine fitted with 8-mm diameter flat-faced punches was used to measure scraper pressure (SCR), a type of shear stress, to evaluate sticking behavior. The shear stress between the surfaces of the tablet and lower punch was determined using an SCR detection system. Mean surface roughness (Ra) of tablets, measured by a scanning laser-microscope, was used to estimate the magnitude of sticking. Tablet tensile strength tended to increase with compression pressure at either of the tablet production velocities tested, which was consistent with previous reports. SCR decreased with increasing compression pressure for samples at all compression velocities, and showed a tendency to increase with binder concentration. SCR also tended to increase with compression velocity for samples at all compression pressures, suggesting that the frequency of tablet sticking increased as compression velocity increased. Ra associated with sticking increased with SCR, indicating that the adhesive force between the particles of the tablet surface and the lower punch surface plays an important role in sticking.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 58 (12), 1565-1568, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679149120256
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- NII論文ID
- 130000405680
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10894755
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可