Reduction of the amidine C=N bond of 7-aminofurazano(3,4-d)-pyrimidines with sodium borohydride.

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公開日
1976
DOI
  • 10.1248/cpb.24.235
公開者
公益社団法人 日本薬学会

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説明

Reduction of 5-phenyl-7-substituted aminofurazano (3, 4-d) pyrimidines with sodium borohydride was undertaken. In a sharp contrast with the cases of amino, alkylamino and tosylamino derivatives, the presence of acetyl group on the C7-amino function results in the smooth reduction of the amidine C=N bond to give 7-acetamido-6, 7-dihydro derivative. The presence of benzoyl group led to the formation of 6, 7-dihydro derivative accompanied with loss of benzamide. Analogously, reduction of 5-phenyl-7-ethylthiofurazano (3, 4-d) pyrimidine gave the 6, 7-dihydro derivative.

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