Effects of Pathological Conditions on Ocular Pharmacokinetics of Antimicrobial Drugs

DOI Web Site Web Site 被引用文献3件 参考文献17件
  • Ueda Kayoko
    Research Laboratories Senju Pharmaceutical Co., Ltd. Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology
  • Ohtori Akira
    Research Laboratories Senju Pharmaceutical Co., Ltd.
  • Tojo Kakuji
    Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology

この論文をさがす

抄録

A diffusion model of ocular pharmacokinetics was used to estimate the effects of pathological conditions on ocular pharmacokinetics. In vivo rabbit data after topical instillation of ciprofloxacin and ofloxacin were compared with the simulated concentrations in the aqueous and vitreous humors. The barrier capacity of the surrounding membranes such as the retina/choroid/sclera (RCS) membrane and the cornea was characterized by dimensionless Sherwood number derived by the pseudo-steady state approach (PSSA). We assumed the barrier capacity decreased by inflammation; when the barrier capacity of the RCS membrane and the cornea was assumed to be one-tenth for the RCS membrane and a half for the cornea respectively, the in vivo data agreed with the simulated profile without contradiction. The drug concentration gradient simulated in the vitreous body near the RCS membrane was more significant in the inflamed eyes than in the normal eyes, suggesting that the elimination of the drugs from the RCS membrane was enhanced by inflammation. The present diffusion model can better describe the ocular pharmacokinetics in both normal and diseased conditions.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (17)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ