Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells

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  • Tung Nguyen Huu
    College of Pharmacy, Chungnam National University Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Song Gyu Yong
    College of Pharmacy, Chungnam National University
  • Minh Chau Van
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Kiem Phan Van
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Jin Long Guo
    College of Pharmacy, Chungnam National University
  • Boo Hye-Jin
    Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University
  • Kang Hee-Kyoung
    Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University
  • Kim Young Ho
    College of Pharmacy, Chungnam National University

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抄録

Three new dammarane-type glycosides, named ginsenosides SL1—SL3 (1—3), and eleven known compounds (4—14) were isolated from the heat-processed leaves of Panax ginseng. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Cytotoxic-activity testing of compounds 1—14 against human leukemia HL-60 cells showed that ginsenosides Rh3 (11) and Rk2 (12) exhibited potent effects with IC50 values of 0.8 and 0.9 μM. In addition, ginsenosides SL3 (3), 20S-Rg2 (7), F4 (10), 20S-Rh2 (13) displayed strong activity with IC50 values of 9.0, 9.0, 7.5, and 8.2 μM, respectively. This is the first report on chemical components of the steamed ginseng leaves.

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