Studies on Cyclophosphamide Metabolites and Their Related Compounds. I

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Two crystalline metabolites (2, 3) of cyclophosphamide (1) were isolated from rabbit urine. The structures of 2 and 3 were determined from their physicochemical data, and confirmed by synthesis. The positions of 2 and 3 in the metabolic pathway of 1 in living animals were discussed briefly.

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