A quadruped study on chitosan microspheres containing atorvastatin calcium: preparation, characterization, quantification and in-vivo application
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- Eroglu Hakan
- Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University
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- Nemutlu Emirhan
- Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University
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- Turkoglu Omer Faruk
- Department of Neurosurgery, Ankara Ataturk Research & Education Hospital
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- Nacar Osman
- Department of Neurosurgery, Ankara Numune Research & Education Hospital
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- Bodur Ebru
- Department of Biochemistry, Faculty of Medicine, Hacettepe University
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- Sargon Mustafa Fevzi
- Department of Anatomy, Faculty of Medicine, Hacettepe University
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- Beskonakli Etem
- Department of Neurosurgery, Ankara Ataturk Research & Education Hospital
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- Oner Levent
- Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University
書誌事項
- タイトル別名
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- A Quadruped Study on Chitosan Microspheres Containing Atorvastatin Calcium: Preparation, Characterization, Quantification and <i>in-Vivo</i> Application
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抄録
Atorvastatin is commonly used as a cholesterol lowering agent in patients. Recently, the neuroprotective effects of atorvastatin became the focus of many research studies. In this study, we have formulated chitosan microspheres containing atorvastatin calcium. In-vitro characterization of chitosan microspheres and quantification of atorvastatin calcium from formulations were also evaluated. The neuroprotective efficiency of atorvastatin calcium was investigated by an experimental spinal cord injury model. Atorvastatin calcium microspheres were implanted at the laminectomy area (1 mg/kg) immediately after trauma. Twenty-four hours after injury, motor functions of animals were scored according to modified Tarlov Scale. In spinal cord tissues tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and lipid peroxidation levels were quantified and ultrastructural changes have been investigated. The results of all parameters indicate that microspheres containing atorvastatin calcium were capable of improving functional outcome, attenuating the expression of TNF-α, IL-1β and IL-6; lowering lipid peroxidation levels and maintaining the preservation of the cellular uniformity.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 58 (9), 1161-1167, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679149648128
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- NII論文ID
- 130000324589
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10796424
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可