Xanthone and Benzophenone Glycosides from the Stems of Cratoxylum formosum ssp. pruniflorum

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  • Duan Ying-hui
    College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
  • Dai Yi
    Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
  • Wang Guang-hui
    Institute for Biomedical Research, Xiamen University
  • Chen Hai-feng
    Institute for Biomedical Research, Xiamen University
  • Gao Hao
    Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
  • Chen Jie-bo
    Sanford-Burnham Medical Research Institute, Cancer Center
  • Yao Xin-sheng
    College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
  • Zhang Xiao-kun
    Institute for Biomedical Research, Xiamen University Sanford-Burnham Medical Research Institute, Cancer Center

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Two new xanthone glycosides, namely pruniflorosides A and B (1, 2), a new benzophenone glycoside, prunifloroside C (3), and a new xanthone, pruniflorone S (4) were isolated from the stems of Cratoxylum formosum ssp. pruniflorum, along with six known xanthones (5—10). Their structures were determined on the basis of extensive spectroscopic analysis. In addition, their retinoid X receptor α (RXRα) transcriptional activities were evaluated in vitro.

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