Azaphilone and Isocoumarin Derivatives from the Endophytic Fungus Penicillium sclerotiorum PSU-A13

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  • Arunpanichlert Jiraporn
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University
  • Rukachaisirikul Vatcharin
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University
  • Sukpondma Yaowapa
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University
  • Phongpaichit Souwalak
    Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songkla University
  • Tewtrakul Supinya
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University
  • Rungjindamai Nuttawut
    National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand
  • Sakayaroj Jariya
    National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand

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Two new azaphilone derivatives, penicilazaphilones A (1) and B (2), and one new isocoumarin, penicilisorin (3), together with six known compounds were isolated from the endophytic fungus Penicillium sclerotiorum PSU-A13. Their structures were identified by analysis of spectroscopic data. The antimicrobial activity against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans as well as the inhibitory effect on human immunodeficiency virus (HIV)-1 integrase and protease were examined.

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