Synthesis and antibacterial activity of some novel 6-(1H-benz〔d〕imidazol-2-yl)-8-(5-nitro-2-furyl)-3-(4-pyridyl)-7,8-dihydro〔1,2,4〕triazolo〔3,4-b〕〔1,3,4〕thiadiazepines

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  • Malla Reddy Vanga
    Dr. Ch. Ravishanker Memorial Medicinal Chemistry Research Laboratory, University College of Pharmaceutical Sciences, Kakatiya University
  • Ravinder Reddy Kunduru
    Dr. Ch. Ravishanker Memorial Medicinal Chemistry Research Laboratory, University College of Pharmaceutical Sciences, Kakatiya University

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  • Synthesis and Antibacterial Activity of Some Novel 6-(1H-Benz[d]imidazol-2-yl)-8-(5-nitro-2-furyl)-3-(4-pyridyl)-7,8-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines

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A new series of novel 6-(1H-benz[d]imidazol-2-yl)-8-(5-nitro-2-furyl)-3-(4-pyridyl)-7,8-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines 8a—d has been synthesized. These compounds were evaluated for their efficiency as antibacterial agents against two Gram-positive and Gram-negative strains of bacteria along with antifungal activity against two fungal organisms. The antibacterial and antifungal activities of the present compounds were not comparable with those of the standard drugs employed. But, however, all the test compounds could exhibit notable activities only at higher concentrations (250, 500 μg/ml). The chemical structures of these compounds were confirmed on the basis of spectral data.

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