Block Ionomer Complex Micelles Based on the Self-Assembly of Poly(ethylene glycol)-block-poly(acrylic acid) and CdCl2 for Anti-tumor Drug Delivery

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  • An Liping
    School of Public Health, Jilin University College of Pharmacy, Beihua University
  • Wang Yapei
    Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University
  • Liu Xiaomei
    School of Public Health, Jilin University
  • Ma Ning
    Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University
  • Du Haiying
    School of Public Health, Jilin University
  • Jin Minghua
    School of Public Health, Jilin University
  • Liu Ying
    Department of Toxicology and Sanitary Chemistry, School of Public Health and Family Medicine, Capital Medical University
  • Zhang Long
    School of Public Health, Jilin University
  • Xu Yanling
    School of Public Health, Jilin University
  • Huang Peili
    Department of Toxicology and Sanitary Chemistry, School of Public Health and Family Medicine, Capital Medical University
  • Sun Zhiwei
    School of Public Health, Jilin University Department of Toxicology and Sanitary Chemistry, School of Public Health and Family Medicine, Capital Medical University

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A novel block ionomer complex micelles as drug carrier is developed utilizing self-assemble of poly(ethylene glycol)-block-poly(acrylic acid) (PEG-b-PAA) and cadmium chloride. This micelles are characterized to be have good bio-compatibility, hydrophilicity, passive targeting and sustained slow release property which shows great potential for liver cancer therapy. Block ionomer complex micelles based on PEG-b-PAA and cadmium chloride can self-assemble in distilled water, and Cd2+ agent is entrapped into the core stabilized by PEG shells. Results showed the block ionomer complex micelles to be spherically shaped. Cadmium was incorporated easily into the ionic core with remarkably high efficiency (34.25% weight (wt)/wt). The cadmium-loaded polymeric micelles exhibited sustained and slow release behavior of cadmium and a potent cytotoxicity against SMMC-7721 in vitro. This novel block ionomer complex micelles with cores of metal antitumor drug indicates to be potential carriers for effective drug delivery.

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