Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production
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- Liang Shuang
- School of Pharmacy, Shanghai Jiaotong University Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, People's Republic of China
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- Tian Jun-Mian
- Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, People's Republic of China
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- Feng Yi
- Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, People's Republic of China
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- Liu Xiao-Hua
- Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, People's Republic of China
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- Xiong Zhi
- Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, People's Republic of China
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- Zhang Wei-Dong
- School of Pharmacy, Shanghai Jiaotong University Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, People's Republic of China
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Abstract
Chemical examination of the methanolic extract from the stem bark of Daphne aurantiaca led to the isolation of three new flavonoids (1—3), and 29 known flavonoids. All 32 compounds were isolated for the first time from Daphne aurantiaca. The isolates were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 21 and 24 showed potent inhibitory activities against the production of NO with IC50 values of 0.006 and 0.076 μM, respectively.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 59 (5), 653-656, 2011
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679150048512
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- NII Article ID
- 130000648882
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 11058189
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed