Triterpenoid Saponins from the Seeds of Celosia argentea and Their Anti-inflammatory and Antitumor Activities

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  • Wu Qingbin
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, People's Republic of China
  • Wang Yan
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, People's Republic of China
  • Guo Meili
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, People's Republic of China

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Three new triterpenoid saponins, named celosin E (1), celosin F (2) and celosin G (3), together with a known compound cristatain (4), were isolated from the seeds of Celosia argentea L. (Amaranthaceae). All the isolated compounds were obtained for the first time from this plant. The structures of new compounds were characterized on the basis of extensive NMR experiments and mass spectrometry data. The antitumor and anti-inflammatory activities of the four compounds were tested in vitro.

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