Oplopanphesides A-C, Three New Phenolic Glycosides from the Root Barks of Oplopanax horridus

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  • Huang Wei-Hua
    Institute of Chinese Medical Sciences, University of Macau
  • Zhang Qing-Wen
    Institute of Chinese Medical Sciences, University of Macau
  • Meng Lan-Zhen
    Institute of Chinese Medical Sciences, University of Macau
  • Yuan Chun-Su
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago
  • Wang Chong-Zhi
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago
  • Li Shao-Ping
    Institute of Chinese Medical Sciences, University of Macau

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Three new phenolic glycosides, named oplopanphesides A—C (1—3), have been isolated from the root barks of Oplopanax horridus. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques. These phenolic glycosides possess a novel feature in their sugar moieties that a 3-hydroxy-3-methylglutaryl moiety was connected with C-6 of the β-D-glucopyranosyl group. Those compounds showed no cytotoxic effects against human cancer cell lines (MDA-231 and MCF-7) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.

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