Preparation and Characterization of 5-Fluorouracil Loaded Chitosan Microspheres by a Two-Step Solidification Method
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- Sun Yi
- Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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- Gu Lei
- Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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- Gao Yuan
- Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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- Gao Feng
- Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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説明
Chitosan, as a natural biopolymer, has potential applications in controlling the release of drugs due to its unique natural and physiochemical properties. Conventionally, an emulsion crosslinking method was used to prepare chitosan microspheres. In this study, a novel method of preparing 5-fluorouracil-loaded chitosan microspheres was established by combining the emulsification technique and a two-step solidification method using both glutaraldehyde (GTA) and tripolyphosphate (TPP) as crosslinking agents. The microspheres were characterized by surface morphology, encapsulation efficiency, yield of microspheres and drug release profile in vitro. The optimal chitosan microspheres were achieved by crosslinking chitosan with both TPP (0.1%, pH 4.0) and GTA (1.0%, v/v) with span-80 additive under a crosslinking time of 1 h with TPP and GTA, respectively.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 58 (7), 891-895, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679150230912
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- NII論文ID
- 130000299779
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10737632
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可