Physico-Chemical Characterization of .GAMMA.-Amino n-Butyric Acid Nanoparticles

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  • Dichi Emma
    Matériaux et Santé, EA 401 Faculté de Pharmacie, Université Paris-Sud
  • Sghaier Mehrez
    Matériaux et Santé, EA 401 Faculté de Pharmacie, Université Paris-Sud
  • Fraisse Bernard
    Laboratoire Institut Charles Gerhardt (UMR 5253)
  • Bonhomme François
    Laboratoire PPB, UMR CNRS 8612, Faculté de Pharmacie, IFR 141, Université Paris-Sud

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  • Physico-chemical characterization of γ-amino n-butyric acid nanoparticles
  • Physico chemical characterization of g amino n butyric acid nanoparticles

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This work deals with the preparation and characterization of high-purity nanoparticles of γ-amino n-butyric acid (GABA) in order to enhance the efficiency of this drug. A sublimation procedure at low pressure was applied to GABA after improving the experimental parameters of this physical transformation. The elaboration of the molecule is solvent-free. The process does not change the chemical formula of the compound but modifies its physico-chemical characteristics. In this work, we present the experimental parameters for preparing monoclinic GABA nanoparticles. Their identification and physico-chemical properties were determined with a large number of investigations: Powder X-ray diffraction (PXRD), density and purity measurements, differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA), calorimetric measurements (ΔHdissolution and Cp), thermally stimulated current (TSC), and electrochemical impedance.

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