Studies on the syntheses of analgesics. VI. Synthesis of 1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine derivatives.
書誌事項
- 公開日
- 1975
- 資源種別
- journal article
- DOI
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- 10.1248/cpb.23.1932
- 公開者
- 公益社団法人 日本薬学会
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説明
Continuing our study of new types of non-narcotic analgesics, we synthesized several 1, 2, 3, 4, 5, 6-hexahydro-6, 6-dimethyl-1, 5-methano-3-benzazocine derivatives from ethyl 4-methoxyphenylacetate via the ring closure reaction of 5-(1-hydroxy-1-methylethyl)-3-(4-methoxyphenyl)-2-piperidinone (V). The by-product which was produced by the ring closure reaction of V, was presumed to be 1, 2, 3, 4, 5, 6-hexahydro-8-methoxy-6, 6-dimethyl-9-sulfo-1, 5-methano-3-benzazocine (VII). The synthesized compounds were tested for analgesic activity in mice.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 23 (9), 1932-1937, 1975
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679150778624
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- NII論文ID
- 110003622131
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 1182908
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- 本文言語コード
- en
-
- 資料種別
- journal article
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- データソース種別
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- JaLC
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- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可