Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis

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  • Lu Yi
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Taiwan
  • Su Jui-Hsin
    Department of Biological Science and Technology, Meiho Institute of Technology
  • Huang Chiung-Yao
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Taiwan
  • Liu Yung-Chun
    Department of Biological Science and Technology, Meiho Institute of Technology
  • Kuo Yao-Haur
    National Research Institute of Chinese Medicine, Taiwan
  • Wen Zhi-Hong
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Taiwan
  • Hsu Chi-Hsin
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Taiwan
  • Sheu Jyh-Horng
    Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Taiwan Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Taiwan

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Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of Sinularia querciformis also afforded one new cembranoid, querciformolide E (3), along with four known cembranoids 4—7. The structures of these compounds were elucidated on the basis of their spectroscopic data. Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.

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