An Artificial Copper Complex Incorporating a Cell-Penetrating Peptide Inhibits Nuclear Factor-.KAPPA.B (NF-.KAPPA.B) Activation
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- Kanemaru Yosuke
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Momiki Yumi
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Matsuura Saori
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Horikawa Tatsufumi
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Gohda Jin
- Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University
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- Inoue Jun-ichiro
- Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University
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- Okamoto Yoshinari
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Fujita Mikako
- Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo
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- Otsuka Masami
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
Bibliographic Information
- Other Title
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- An Artificial Copper Complex Incorporating a Cell-Penetrating Peptide Inhibits Nuclear Factor-κB (NF-κB) Activation
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Abstract
Nuclear factor-κB (NF-κB) is an inducible transcription factor activated by a variety of cytokines, and promotes the transcription of genes involved in cancer, inflammation, autoimmune disease, and viral infection, among others. Because of its involvement in numerous disease processes, considerable research has focused on NF-κB as a potential drug target. We previously reported that cupric ion (Cu2+) blocks NF-κB activation. However, Cu2+ is unsuitable for drug applications. The copper complex of an artificial peptide HPH-Pep (HPH-Pep-Cu2+) was a promising alternative, but it did not easily cross the cell membrane. We report the development of a NF-κB inhibiting Cu2+ complex with improved cell-penetrating activity arising from the coupling of a Tat peptide to HPH-Pep-Cu2+.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 59 (12), 1555-1558, 2011
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679150904064
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- NII Article ID
- 130001852132
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 023321247
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed