Antiproliferative Activity of Amathaspiramide Alkaloids and Analogs
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- Shimokawa Jun
- Graduate School of Pharmaceutical Sciences, Nagoya University
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- Chiyoda Koji
- Graduate School of Pharmaceutical Sciences, University of Tokyo
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- Umihara Hirotatsu
- Graduate School of Pharmaceutical Sciences, University of Tokyo
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- Fukuyama Tohru
- Graduate School of Pharmaceutical Sciences, Nagoya University
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<p>Assisted by the total syntheses of all the amathaspiramides, six natural products and four synthetic intermediates with partially fluctuating structures were prepared and subjected to a growth inhibition assay in four human cancer cell lines. The results showed amathaspiramides A, C, and E had moderate antiproliferative activity. Examination of the structure–activity relationship revealed the importance of the amine or imine substructure on the pyrrolidine moiety and the 8R stereochemistry on the N-acyl hemiaminal moiety for the antiproliferative activity of amathaspiramide alkaloids.</p>
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 64 (8), 1239-1241, 2016
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679153234304
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- NII論文ID
- 130005253895
- 40020899731
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 027523298
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- PubMed
- 27169437
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
