Highlighted Paper selected by Editor-in-Chief : Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives
-
- Kobayashi Hiroyuki
- Division of Organic Chemistry, National Institute of Health Sciences Department of Chemistry and Life Science, Kogakuin University
-
- Misawa Takashi
- Division of Organic Chemistry, National Institute of Health Sciences
-
- Oba Makoto
- Graduate School of Biomedical Sciences, Nagasaki University
-
- Hirata Naoya
- Division of Pharmacology, National Institute of Health Sciences
-
- Kanda Yasunari
- Division of Pharmacology, National Institute of Health Sciences
-
- Tanaka Masakazu
- Graduate School of Biomedical Sciences, Nagasaki University
-
- Matsuno Kenji
- Department of Chemistry and Life Science, Kogakuin University
-
- Demizu Yosuke
- Division of Organic Chemistry, National Institute of Health Sciences
書誌事項
- タイトル別名
-
- Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives
この論文をさがす
説明
<p>We designed and synthesized a series of cell-penetrating peptides containing cationic proline derivatives (ProGu) that exhibited responsive changes in their secondary structures to the cellular environment. Effects of the peptide length and steric arrangement of the side chain in cationic proline derivatives [Pro4SGu and Pro4RGu] on their secondary structures and cell membrane permeability were investigated. Moreover, peptides 3 and 8 exhibited efficient intracellular delivery of plasmid DNA.</p>
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 66 (5), 575-580, 2018-05-01
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679153300224
-
- NII論文ID
- 130006729546
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 028958820
-
- PubMed
- 29710053
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可