Preparation and Characterization of Amphiphilic Calixarene Nanoparticles as Delivery Carriers for Paclitaxel
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- Zhao Zi-Ming
- Department of Pharmacy, Xuzhou Medical College Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy
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- Wang Yu
- Department of Pharmacy, Xuzhou Medical College Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy
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- Han Jin
- Department of Pharmacy, Xuzhou Medical College Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy
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- Zhu Hui-Dong
- Department of Pharmacy, Xuzhou Medical College
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- An Lin
- Department of Pharmacy, Xuzhou Medical College Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy
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Two types of amphoteric calix[n]arene carboxylic acid (CnCA) derivative, i.e., calix[6]arene hexa-carboxylic acid (C6HCA) and calix[8]arene octo-carboxylic acid (C8OCA), were synthesized by introducing acetoxyls into the hydroxyls of calix[n]arene (n=6, 8). C6HCA and C8OCA nanoparticles (NPs) were prepared successfully using the dialysis method. CnCA NPs had regular spherical shapes with an average diameter of 180–220 nm and possessed negative charges of greater than −30 mV. C6HCA and C8OCA NPs were stable in 4.5% bovine serum albumin solutions and buffers (pH 5–9), with a low critical aggregation concentration value of 5.7 mg·L−1 and 4.0 mg·L−1, respectively. C6HCA and C8OCA NPs exhibited good paclitaxel (PTX) loading capacity, with drug loading contents of 7.5% and 8.3%, respectively. The overall in vitro release behavior of PTX from the CnCA NPs was sustained, and C8OCA NPs had a slower release rate compared with C6HCA NPs. These favorable properties of CnCA NPs make them promising nanocarriers for tumor-targeted drug delivery.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 63 (3), 180-186, 2015
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679153304064
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- NII論文ID
- 130004803773
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 026193082
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- PubMed
- 25757488
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可