Four New Lignans and IL-2 Inhibitors from Magnoliae Flos

DOI Web Site Web Site PubMed 2 Citations 31 References
  • Nguyen Thi Tuyet Mai
    College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University
  • Lee Hyun-Su
    College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology
  • Nguyen Thi Thu
    College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University
  • Ngo Thi Quynh Mai
    College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu
  • Jun Chang-Duk
    School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology
  • Min Byung Sun
    College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu
  • Kim Jeong Ah
    College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University

Bibliographic Information

Other Title
  • Highlighted Paper selected by Editor-in-Chief : Four New Lignans and IL-2 Inhibitors from Magnoliae Flos

Search this article

Description

<p>Four new lignans, a furofuran lignan medioresinol B (10) and three tetrahydrofuran lignans kobusinol C (16), 7′-methoxy magnostellin A (21), and mangnostellin D (23), along with 19 known lignans, were isolated from the flower buds of Magnolia biondii PAMP. The structures of the isolates were elucidated using spectroscopic analysis, mainly one- and two-dimensional NMR, high resolution-MS, and circular dichroism techniques as well as Mosher’s esterification method. The anti-allergic effects of the isolated compounds were evaluated by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T-cells. Compounds 11–14 reduced IL-2 expression in a dose-dependent manner.</p>

Journal

Citations (2)*help

See more

References(31)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top