Synthesis of Novel Indole Hydrazone Derivatives and Evaluation of Their Antiplatelet Aggregation Activity
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- Mashayekhi Vida
- Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
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- Haj Mohammad Ebrahim Tehrani Kamaleddin
- Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
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- Amidi Salimeh
- Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
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- Kobarfard Farzad
- Phytochemistry Research Centre, Shahid Beheshti University of Medical Sciences Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
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Description
Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new indole hydrazone derivatives were evaluated for their ability to inhibit platelet aggregation induced by adenosine diphosphate (ADP) and arachidonic acid (AA). Compounds 1h and 3h exhibited remarkable activity against arachidonic acid induced platelet aggregation with IC50 values comparable to that of indomethacin and compound 1i efficiently inhibited platelet aggregation induced by both ADP and AA.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 61 (2), 144-150, 2013
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679153696768
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- NII Article ID
- 130002460105
- 40019558517
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3s7js1agtw%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 024220168
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- PubMed
- 23154304
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed