Synthesis of Novel Indole Hydrazone Derivatives and Evaluation of Their Antiplatelet Aggregation Activity

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  • Mashayekhi Vida
    Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
  • Haj Mohammad Ebrahim Tehrani Kamaleddin
    Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
  • Amidi Salimeh
    Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences
  • Kobarfard Farzad
    Phytochemistry Research Centre, Shahid Beheshti University of Medical Sciences Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences

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Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new indole hydrazone derivatives were evaluated for their ability to inhibit platelet aggregation induced by adenosine diphosphate (ADP) and arachidonic acid (AA). Compounds 1h and 3h exhibited remarkable activity against arachidonic acid induced platelet aggregation with IC50 values comparable to that of indomethacin and compound 1i efficiently inhibited platelet aggregation induced by both ADP and AA.

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