Studies on powdered preparations,pt.6

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  • Studies on Powdered Preparations. VI. Theoretical Consideration of Tablet Disintegration Process by Thermal Analysis.

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The characteristic values of tablet disintegration by thermal analysis were considered theoretically and their physical meaning was examined. The graphic surface area, α, enclosed by the curve of surface area in solution and time axis, was calculated for a powder system and it was proved that the value of α was constant for the same substance and experimental conditions. Moreover it was proved theoretically and experimentally that the graphic surface area of the same weight of powder was constant in total amount when the powder was divided and measured. This result of a powder could be applied to a tablet and the integral snrface area of a tablet was constant for the same weight. The experimental results agreed with this theory, and it was proved that the meaning of S2×t3 was similar to the integral surface area. The mean volume surface diameter is related to the largest particle size evaluated in tablet disintegration. From these theoretical considerations, the physical meaning of the value of U. S. P. method was discussed and elucidated.

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