Thermotropic Phase Behavior of Hydrogenated Soybean Phosphatidylcholine–Cholesterol Binary Liposome Membrane
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- Kitayama Hiroki
- Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
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- Takechi Yuki
- Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
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- Tamai Nobutake
- Department of Life System, Institute of Technology and Science, The University of Tokushima
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- Matsuki Hitoshi
- Department of Life System, Institute of Technology and Science, The University of Tokushima
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- Yomota Chikako
- National Institute of Health Sciences
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- Saito Hiroyuki
- Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
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By combination of differential scanning calorimetry (DSC) and fluorescence spectroscopy of 6-propionyl-2-(dimethylamino)naphthalene (Prodan), we elucidated the thermotropic phase behavior of hydrogenated soybean phosphatidylcholine (HSPC)–cholesterol binary liposome membrane which has similar lipid composition to Doxil®, the widely used liposome product in treatment of various tumors. We found that the characteristic points at cholesterol mole fraction (Xch)=0.023 and 0.077 correspond to the hexagonal lattice, in which cholesterol molecules are considered to be regularly distributed in all regions of HSPC lipid bilayer with 1 : 42 and 1 : 12 units, respectively, as static averaged structures. Apparent endothermic peak disappeared at Xch=0.40 in the DSC thermograms, indicating the existence of single liquid ordered phase at Xch>0.40. In addition, fluorescence measurements of Prodan and its lauroyl derivative in poly(ethylene glycol) (PEG)-modified liposomes indicated that PEG modification has a negligible effect on the phase behavior of HSPC–cholesterol binary liposome membrane. These results may provide useful information in developing novel liposome products whose stability and encapsulated drug release are controlled.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 62 (1), 58-63, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679153790464
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- NII論文ID
- 130003381805
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2czitFKgug%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 025136109
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- PubMed
- 24390493
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可