Cardioactive C₁₉-Diterpenoid Alkaloids from the Lateral Roots of Aconitum carmichaeli "Fu Zi"

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  • Liu Xiu-Xiu
    Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University
  • Jian Xi-Xian
    Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
  • Cai Xiu-Feng
    Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University
  • Chao Ruo-Bing
    Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University
  • Chen Qiao-Hong
    Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
  • Chen Dong-Lin
    Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
  • Wang Xiao-Liang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences
  • Wang Feng-Peng
    Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University

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  • Cardioactive C<sub>19</sub>-Diterpenoid Alkaloids from the Lateral Roots of <i>Aconitum carmichaeli</i> “Fu Zi”

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Bioassay-guided fractionation of an n-BuOH extract of the lateral roots of Aconitum carmichaeli. led to the isolation of 5 cardioactive C19-diterpenoid alkaloids: N-deethylaconine (1), beiwutinine (2), hypaconine (3), mesaconine (4), and 15α-hydroxyneoline (5). N-Deethylaconine and beiwutinine are new aconitine-type C19-diterpenoid alkaloids. Hypaconine was isolated from this species for the first time. Among them, mesaconine, hypaconine, and beiwutinine showed the strongest cardiac actions on the isolated perfused bullfrog heart. Furthermore, mesaconine has protective effects, including improved inotropic effect and left ventricular diastolic function, on myocardial ischemia-reperfusion injury in rat at a dose of 10−9 mol/L. However, mesaconine has almost no effect on heart rate.

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