Cytotoxic Biscembranoids from the Soft Coral <i>Sarcophyton pauciplicatum</i>
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- Nam Nguyen Hoai
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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- Tung Pham The
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) School of Chemical Engineering, Hanoi University of Science and Technology
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- Ngoc Ninh Thi
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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- Hanh Tran Thi Hong
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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- Thao Nguyen Phuong
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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- Thanh Nguyen Van
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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- Cuong Nguyen Xuan
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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- Thao Do Thi
- Institute of Biotechnology, VAST
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- Huong Tran Thu
- School of Chemical Engineering, Hanoi University of Science and Technology
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- Thung Do Cong
- Institute of Marine Environment and Resources, VAST
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- Kiem Phan Van
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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- Kim Young Ho
- College of Pharmacy, Chungnam National University
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- Minh Chau Van
- Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Bibliographic Information
- Other Title
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- Cytotoxic Biscembranoids from the Soft Coral Sarcophyton pauciplicatum
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Abstract
Ten biscembranoids (1–10), including the two new compounds sarcophytolides M and N (1 and 2), were isolated from the methanol extract of the Vietnamese soft coral Sarcophyton pauciplicatum. Their structures were elucidated by spectroscopic methods including one dimensional (1D)- and 2D-NMR, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and circular dichroism (CD). The in vitro cytotoxic activity of all isolated compounds against a panel of eight human cancer cell lines including HepG2 (hepatoma cancer), HL-60 (acute leukemia), KB (epidermoid carcinoma), LNCaP (prostate cancer), LU-1 (lung cancer), MCF7 (breast cancer), SK-Mel2 (melanoma), and SW480 (colon adenocarcinoma) was evaluated using the sulforhodamine B colorimetric assay. Among the isolated biscembranoids, 1, 3, 4, 7, 9, and 10 exhibited significant cytotoxic effects and may be selected for further studies of their anticancer activity.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 63 (8), 636-640, 2015
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679153872512
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- NII Article ID
- 130005090111
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 026616894
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- PubMed
- 26235170
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed