Synthesis and Biological Evaluation of Raddeanin A, a Triterpene Saponin Isolated from <i>Anemone raddeana</i>

DOI Web Site Web Site PubMed 1 Citations 2 References

Bibliographic Information

Other Title
  • Synthesis and Biological Evaluation of Raddeanin A, a Triterpene Saponin Isolated from Anemone raddeana

Search this article

Abstract

First, Raddeanin A, a cytotoxic oleanane-type triterpenoid saponin isolated from Anemone raddeana REGEL, was synthesized. Stepwise glycosylation was adopted in the synthesis from oleanolic acid, employing arabinosyl, glucosyl and rhamnosyl trichloroacetimidate as donors. The chemical structure of Raddeanin A was confirmed by means of 1H-NMR, 13C-NMR, IR, MS and elemental analysis, which elucidated the structure to be 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside oleanolic acid. Biological activity tests showed that in the range of low concentrations, Raddeanin A displayed moderate inhibitory activity against histone deacetylases (HDACs), indicating that the HDACs’ inhibitory activity of Raddeanin A may contribute to its cytotoxicity.

Journal

Citations (1)*help

See more

References(2)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top