Inhibition of Human Enterovirus 71 Replication by Pentacyclic Triterpenes and Their Novel Synthetic Derivatives

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  • Zhao Chun-hui
    School of Life Sciences, Liaoning Normal University Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery
  • Xu Jie
    School of Life Sciences, Liaoning Normal University
  • Zhang Ying-qiu
    Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Institute of Cancer Stem Cell, Dalian Medical University
  • Zhao Long-xuan
    Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery
  • Feng Bin
    Department of Biotechnology, Dalian Medical University

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A large number of bioactive pentacyclic triterpenoids have been shown to have multiple biological activities. This study was conducted to evaluate the inhibitory activities of 6 newly synthesized and novel pentacyclic triterpenoids against enterovirus 71 (EV71). The parent compound, ursolic acid (UA), showed the greatest inhibitory activity against EV71, while oleanolic acid (OA), asiatic acid (AA), and synthetic derivatives of 18-β-glycyrrhetinic acid (GA) and OA also exhibited inhibitory effects, although to lesser extents. The results suggest these compounds show potential for further optimization as antiviral candidates for treatment of EV71 infections.

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